Cyclin E1-CDK 2, a potential anticancer target
نویسندگان
چکیده
منابع مشابه
Cyclin E1-CDK 2, a potential anticancer target
CCNE1 is one of the most frequent gene amplifications in high grade serous ovarian cancers (HGSOCs), which occurs in at least 20% of HGSOC and in 30% of established ovarian cancer cell lines. Studies with both primary and metastatic ovary tumor specimens further suggest that the abundance of CCNE1 protein expression correlates with tumor progression and predicts a poor prognosis in ovarian canc...
متن کاملCyclin-dependent kinase 2 is an ideal target for ovary tumors with elevated cyclin E1 expression
CCNE1 gene amplification is present in 15-20% ovary tumor specimens. Here, we showed that Cyclin E1 (CCNE1) was overexpressed in 30% of established ovarian cancer cell lines. We also showed that CCNE1 was stained positive in over 40% of primary ovary tumor specimens regardless of their histological types while CCNE1 staining was either negative or low in normal ovary and benign ovary tumor tiss...
متن کاملCyclin E1 and RTK/RAS signaling drive CDK inhibitor resistance via activation of E2F and ETS
High-grade serous ovarian cancers (HGSOC) are genomically complex, heterogeneous cancers with a high mortality rate, due to acquired chemoresistance and lack of targeted therapy options. Cyclin-dependent kinase inhibitors (CDKi) target the retinoblastoma (RB) signaling network, and have been successfully incorporated into treatment regimens for breast and other cancers. Here, we have compared m...
متن کاملBinding of HTm 4 to KAP / CDK 2 / Cyclin A complex enhances the phosphatase activity of KAP , dissociates Cyclin A , and facilitates KAP dephosphorylation of CDK 2
1 Department of Nutrition, Kyushu Women’s University, Jiyugaoka 1-1, Kitakyushushi 807-8586, Japan; 2 Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; 3 Queen’s Center for Biomedical Research, Queen’s Medical Center, Honolulu, HI 96813, USA; 4 Department of Health Promotion & Human Behavior, Kyoto University Graduate School of Public H...
متن کاملProtein phosphatase 2A as a potential target for anticancer therapy.
The kinase oncogenes are well-characterized drivers of cancer development, and several targeted therapies focused on both specific and selectively nonselective kinase inhibitors have now been approved for clinical use. In contrast, much less is known about the role of protein phosphatases, although modulation of their activities might form the foundation for an effective anti-cancer approach. T...
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ژورنال
عنوان ژورنال: Aging
سال: 2016
ISSN: 1945-4589
DOI: 10.18632/aging.100946